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This study aimed to assess the degree of potential temperature and precipitation change as predicted by the HadCM3 (Hadley Centre Coupled Model, version 3) climate model for Louisiana, and to investigate the effects of potential climate change on surface soil organic carbon (SOC) across Louisiana using the Rothamsted Carbon Model (RothC) and GIS techniques at the watershed scale. Climate data sets at a grid cell of 0.5° × 0.5° for the entire state of Louisiana were collected from the HadCM3 model output for three climate change scenarios: B2, A2, and A1F1, that represent low, higher, and even higher greenhouse gas emissions, respectively. Geo-referenced datasets including USDA-NRCS Soil Geographic Database (STATSGO), USGS Land Cover Dataset (NLCD), and the Louisiana watershed boundary data were gathered for SOC calculation at the watershed scale. A soil carbon turnover model, RothC, was used to simulate monthly changes in SOC from 2001 to 2100 under the projected temperature and precipitation changes. The simulated SOC changes in 253 watersheds from three time periods, 2001–2010, 2041–2050, and 2091–2100, were tested for the influence of the land covers and emissions scenarios using SAS PROC GLIMMIX and PDMIX800 macro to separate Tukey-Kramer (p