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This paper addresses two important issues for large Mediterranean city regions: the differential impact of compact urban ‘growth’ and low-density ‘sprawl’ on land cover changes (LCCs), and their final effect on changing land cover relationships (LCRs). The urban expansion of Rome (Italy) during the last 50 years and the related LCCs were investigated as a paradigmatic example of compact versus dispersed urban development. LCCs were assessed over 5 years (1960, 1974, 1990, 2000, 2006) by analysing diachronically the distribution of 12 land cover categories derived from digital land cover maps covering the entire Nuts-3 prefecture of Rome (5353 km²). LCRs were studied using multi-way data analysis. LCCs were found to have relative differences during ‘growth’ (1960–1990) and ‘sprawl’ (1990–2006) phases. Conversion to urban land uses concentrated in the 1960s and 1970s at the urban fringe, while expanding progressively far from the city in the 1990s and 2000s. During the ‘growth’ phase, the land cover classes with the highest probability of being converted to urban uses were arable lands, annual crops, vineyards and pastures. During the ‘sprawl’ phase, olive groves, orchards and forest surfaces also decreased due to the development of low-density built-up areas and infrastructure. Planning suggestions aimed at mitigating the alteration of the rural landscape through sprawl conditions are discussed.